In vitro activity of BRL 36650, a new penicillin.
نویسندگان
چکیده
Compared with four beta-lactam antibiotics and amikacin, BRL 36650 and BMY-28142 were the most active against 509 Enterobacteriaceae, including cefotaxime-resistant isolates and resistant laboratory mutants. BRL 36650 was more active than aztreonam, ceftazidime, and BMY-28142 against Acinetobacter spp., Pseudomonas aeruginosa, and other Pseudomonas spp.; all strains were inhibited by 2 micrograms/ml or less.
منابع مشابه
BRL-36650: in vitro studies and assessment of serum bactericidal activity after single-dose administration in volunteers.
Ten healthy volunteers received 1 g of BRL-36650, a new formamido-penicillin derivative, given by intravenous infusion over 15 min. Levels in serum were measured microbiologically 30, 60, and 120 min after the start of the 15-min infusion and were (mean +/- standard deviation) 102.7 +/- 28.4, 59.7 +/- 11.5, and 9.6 +/- 1.9 mg/liter, respectively. A total of 10 strains each of Escherichia coli, ...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 29 2 شماره
صفحات -
تاریخ انتشار 1986